loltyler1 
Grandmaster 
Clid 
Diamond IV 
Who wins Karthus vs Senna?
MID.GG has 4 high-elo VODs of this matchup so far, not enough games yet to call it.
Karthus vs Senna at a glance
Ranked record Not enough games yet
Across 27 NA and EUW ranked games in bot lane, Karthus wins 51.9% against Senna. That is too few games to compare with the 53.4% Karthus wins in that role overall.
VOD library Not enough games yet
In our library of 4 high-elo VODs (latest patch 26.17), Karthus won 25% against Senna and averaged 8.5/9.8/13.0. That is not enough games yet to say who the matchup favours.
Pro build
The most played Karthus setup into Senna takes Dark Harvest (Domination and Precision) and builds Liandry's Torment, Zhonya's Hourglass and Shadowflame. It shows up in 2 of 4 games with a 50% win rate. The main alternative is Summon Aery (1 game).
How they built Karthus into Senna
Taken from the 4 VODs on this page, patch 14.1–26.17.
Most played setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Karthus
Every streamer in the library with ranked Karthus games, most games first. Each links to their VODs on MID.GG.
Common questions about Karthus vs Senna
What should Karthus build against Senna?
The most-played setup is the Dark Harvest rune page, taken in 2 of the 4 high-elo VODs on MID.GG, with Liandry's Torment, Zhonya's Hourglass and Shadowflame as its most common core items.
Latest Karthus vs Senna games
The most recent games in this matchup, newest first.
- Defeat loltyler1
Master 
18/12/15K / D / A Patch 26.17 BotWatch in the app - Defeat loltyler1 Master 8/8/13K / D / A Patch 14.4 BotWatch in the app
- Defeat loltyler1 Master 3/8/3K / D / A Patch 14.1 BotWatch in the app
- Victory loltyler1 Master 5/11/21K / D / A Patch 13.24 SupportWatch in the app
Related pages
