Who wins Vayne vs Senna?
Vayne wins 45.1% of 175 NA and EUW ranked games against Senna in bot lane, against 49.3% in that role overall. MID.GG has 3 high-elo VODs of this matchup so far, not enough games yet to call it.
Vayne vs Senna at a glance
Ranked record In line
Across 175 NA and EUW ranked games in bot lane, Vayne wins 45.1% against Senna, in line with the 49.3% Vayne wins in that role overall.
VOD library Not enough games yet
In our library of 3 high-elo VODs (latest patch 26.17), Vayne won 67% against Senna and averaged 8.0/8.0/7.0. That is not enough games yet to say who the matchup favours.
Pro build
The most played Vayne setup into Senna takes Lethal Tempo (Precision and Inspiration) and builds Yun Tal Wildarrows, Fiendhunter Bolts and Infinity Edge. It shows up in 2 of 3 games with a 50% win rate. The main alternative also takes Lethal Tempo but runs Celerity and Nimbus Cloak (1 game).
How they built Vayne into Senna
Taken from the 3 VODs on this page, patch 26.16 and 26.17.
Most played setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Vayne
Every streamer in the library with ranked Vayne games, most games first. Each links to their VODs on MID.GG.
loltyler1 
Grandmaster 
Deft 
Challenger 
GeneralSniper Grandmaster 
DuDu 
Master 
Broxah Master
Common questions about Vayne vs Senna
What should Vayne build against Senna?
The most-played setup is the Lethal Tempo rune page, taken in 2 of the 3 high-elo VODs on MID.GG, with Yun Tal Wildarrows, Fiendhunter Bolts and Infinity Edge as its most common core items.
Latest Vayne vs Senna games
The most recent games in this matchup, newest first.
- Victory Gosu Master
10/6/5K / D / A Patch 26.17 BotWatch in the app - Defeat Gosu Master 8/11/3K / D / A Patch 26.17 BotWatch in the app
- Victory Gosu Master 6/7/13K / D / A Patch 26.16 BotWatch in the app
Related pages
