Peyz 
Who wins Kai'Sa vs Vayne?
Kai'Sa wins 49.8% of 3,538 NA and EUW ranked games against Vayne in bot lane, against 49.0% in that role overall. MID.GG has 6 high-elo VODs of this matchup so far, not enough games yet to call it.
Kai'Sa vs Vayne at a glance
Ranked record In line
Across 3,538 NA and EUW ranked games in bot lane, Kai'Sa wins 49.8% against Vayne, in line with the 49.0% Kai'Sa wins in that role overall.
VOD library Not enough games yet
In our library of 6 high-elo VODs (latest patch 26.17), Kai'Sa won 33% against Vayne and averaged 8.2/5.8/5.8. That is not enough games yet to say who the matchup favours.
Pro build
The most played Kai'Sa setup into Vayne takes Lethal Tempo (Precision and Inspiration) and builds Statikk Shiv, Luden's Echo and Voltaic Cyclosword. It shows up in 2 of 6 games with a 0% win rate. The main alternative also takes Lethal Tempo but runs Triumph and Legend: Alacrity (1 game).
Solo kills by level
A solo kill is a kill on the lane opponent with no assist. The bars over each champion above count them by champion level, from 3,538 NA and EUW ranked games in bot lane; the amber marks are where that champion's kills usually fall.
Kai'Sa's solo kills on Vayne Earlier
Kai'Sa gets 0.5 solo kills per game against Vayne, in line with the 0.5 Kai'Sa averages in bot lane, and 14% of them come before level 6, earlier than the usual 11%.
Vayne's solo kills on Kai'Sa Fewer kills
Vayne gets 0.4 solo kills per game against Kai'Sa, fewer than the 0.4 Vayne averages in bot lane, and 11% of them come before level 6, about the usual 11%.
How they built Kai'Sa into Vayne
Taken from the 6 VODs on this page, patch 26.15–26.17.
Most played setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Kai'Sa
Every streamer in the library with ranked Kai'Sa games, most games first. Each links to their VODs on MID.GG.
stunt 
Grandmaster
Common questions about Kai'Sa vs Vayne
What should Kai'Sa build against Vayne?
The most-played setup is the Lethal Tempo rune page, taken in 2 of the 6 high-elo VODs on MID.GG, with Statikk Shiv, Luden's Echo and Voltaic Cyclosword as its most common core items.
Latest Kai'Sa vs Vayne games
The most recent games in this matchup, newest first.
- Victory Gosu
Master 
8/4/5K / D / A Patch 26.17 BotWatch in the app - Defeat comp_lol
Challenger 14/6/9K / D / A Patch 26.16 BotWatch in the app - Defeat xFSN_Saber Master 4/6/5K / D / A Patch 26.15 BotWatch in the app
- Defeat xFSN_Saber Master 11/9/3K / D / A Patch 26.15 BotWatch in the app
- Defeat loltyler1
Diamond III 3/6/8K / D / A Patch 14.22 BotWatch in the app - Victory Deft Master 9/4/5K / D / A Patch 14.21 BotWatch in the app
Related pages
