loltyler1 
Grandmaster 
Clid 
Diamond IV 
Who wins Karthus vs Vel'Koz?
MID.GG has 2 high-elo VODs of this matchup so far, not enough games yet to call it.
Karthus vs Vel'Koz at a glance
Ranked record Not enough games yet
Across 21 NA and EUW ranked games in bot lane, Karthus wins 66.7% against Vel'Koz. That is too few games to compare with the 53.4% Karthus wins in that role overall.
VOD library Not enough games yet
In our library of 2 high-elo VODs (latest patch 26.16), Karthus won 50% against Vel'Koz and averaged 8.5/9.5/11.0. That is not enough games yet to say who the matchup favours.
Pro build
One Karthus setup into Vel'Koz takes Dark Harvest (Domination and Precision) and builds Liandry's Torment. It shows up in 1 of 2 games. The main alternative is Deathfire Touch (1 game).
How they built Karthus into Vel'Koz
Taken from the 2 VODs on this page, patch 13.1 and 26.16.
One-off setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Karthus
Every streamer in the library with ranked Karthus games, most games first. Each links to their VODs on MID.GG.
Common questions about Karthus vs Vel'Koz
What should Karthus build against Vel'Koz?
No rune page repeats yet in the 2 high-elo VODs on MID.GG; one game ran the Dark Harvest rune page, building Liandry's Torment first.
Latest Karthus vs Vel'Koz games
The most recent games in this matchup, newest first.
- Victory Karhus
Master 
17/9/16K / D / A Patch 26.16 BotWatch in the app - Defeat loltyler1 Master 0/10/6K / D / A Patch 13.1 SupportWatch in the app
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