loltyler1 
Grandmaster 
Clid 
Diamond IV 
Who wins Karthus vs Syndra?
In the 7 high-elo VODs on MID.GG, Karthus won 43%.
Karthus vs Syndra at a glance
Ranked record Below average
Across 84 NA and EUW ranked games in Mid lane, Karthus wins 42.9% against Syndra, 4.2 points lower than the 47.1% Karthus wins in that role overall. That is a small sample, so treat it as a starting point.
VOD library Uphill Small sample
In our library of 7 high-elo VODs (latest patch 16.19), Karthus won 43% against Syndra and averaged 8.4/7.1/5.7. That is a small sample, so treat it as a starting point.
Pro build
The most played Karthus setup into Syndra takes Deathfire Touch (Sorcery and Precision) and builds Blackfire Torch, Shadowflame and Liandry's Torment. It shows up in 7 of 7 games with a 43% win rate.
Solo kills by level
A solo kill is a kill on the lane opponent with no assist. The bars over each champion above count them by champion level, from 84 NA and EUW ranked games in Mid lane; the amber marks are where that champion's kills usually fall.
Karthus's solo kills on Syndra Later
Karthus gets 1.0 solo kills per game against Syndra, in line with the 1.1 Karthus averages in mid lane, and 15% of them come before level 6, later than the usual 27%.
How they built Karthus into Syndra
Taken from the 7 VODs on this page, patch 16.19, 16.18, 16.17.
Most played setup
Runes
Core items
Streamers who play Karthus
Every streamer in the library with ranked Karthus games, most games first. Each links to their VODs on MID.GG.
Common questions about Karthus vs Syndra
What should Karthus build against Syndra?
The most-played setup is the Deathfire Touch rune page, taken in 7 of the 7 high-elo VODs on MID.GG, with Blackfire Torch, Shadowflame and Liandry's Torment as its most common core items.
Which pros and streamers play Karthus?
loltyler1 (392 games), Karhus (310) and lolmalice (203) have the most Karthus VODs on MID.GG, each with their runes, build and full timeline.
Latest Karthus vs Syndra games
The most recent games in this matchup, newest first.
- Victory 14/6/11Karhus
Challenger · Bot Patch 16.19 - Victory 13/8/4Karhus
Master · Mid Patch 16.19 - Victory 2/2/3Karhus Master · Bot Patch 16.18
- Defeat 4/13/6Karhus Challenger · Bot Patch 16.18
- Defeat 11/9/4Karhus Master · Bot Patch 16.17
- Defeat 7/5/4Karhus Master · Mid Patch 16.16
- Defeat 8/7/8Karhus Master · Mid Patch 16.15
