Who wins Vayne vs Karthus?
Vayne wins 39.8% of 103 NA and EUW ranked games against Karthus in bot lane, against 48.1% in that role overall. MID.GG has 6 high-elo VODs of this matchup so far, not enough games yet to call it.
Vayne vs Karthus at a glance
Ranked record In line
Across 103 NA and EUW ranked games in bot lane, Vayne wins 39.8% against Karthus, in line with the 48.1% Vayne wins in that role overall.
VOD library Not enough games yet
In our library of 6 high-elo VODs (latest patch 26.20), Vayne won 33% against Karthus and averaged 10.5/8.3/5.5. That is not enough games yet to say who the matchup favours.
Pro build
The most played Vayne setup into Karthus takes Lethal Tempo (Precision and Sorcery) and builds Essence Reaver, Fiendhunter Bolts and Infinity Edge. It shows up in 2 of 6 games with a 50% win rate.
How they built Vayne into Karthus
Taken from the 6 VODs on this page, patch 26.18–26.20.
Most played setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Vayne
Every streamer in the library with ranked Vayne games, most games first. Each links to their VODs on MID.GG.
loltyler1 
Grandmaster 
Deft 
Challenger 
GeneralSniper Grandmaster 
DuDu 
Master 
Broxah Master
Common questions about Vayne vs Karthus
What should Vayne build against Karthus?
The most-played setup is the Lethal Tempo rune page, taken in 2 of the 6 high-elo VODs on MID.GG, with Essence Reaver, Fiendhunter Bolts and Infinity Edge as its most common core items.
Latest Vayne vs Karthus games
The most recent games in this matchup, newest first.
- Defeat reptile9lol Grandmaster
13/7/5K / D / A Patch 26.20 BotWatch in the app - Defeat Broxah Master 5/8/8K / D / A Patch 26.19 JungleWatch in the app
- Defeat Gosu Master 10/12/7K / D / A Patch 26.18 BotWatch in the app
- Defeat reptile9lol Master 4/12/3K / D / A Patch 26.18 JungleWatch in the app
- Victory Gosu Master 16/3/3K / D / A Patch 26.18 BotWatch in the app
- Victory Gosu Master 15/8/7K / D / A Patch 26.16 BotWatch in the app
Related pages
