BZ_EUW 
Grandmaster 
Clid 
Diamond IV 
Who wins Zed vs Karthus?
In the 5 high-elo VODs on MID.GG, Zed won 60%.
Zed vs Karthus at a glance
VOD library Favoured Small sample
In 5 high-elo games (latest patch 16.17), Zed won 60% against Karthus, so the matchup looks favoured in our library. The average game ended 7.6/4.2/7.8 for Zed. That is a small sample, so treat it as a starting point.
Pro build
One Zed setup into Karthus takes Electrocute (Domination and Inspiration) and builds Voltaic Cyclosword and Edge of Night. It shows up in 1 of 5 games. The main alternative is Conqueror (1 game).
How they built Zed into Karthus
Taken from the 5 VODs on this page, patch 16.17, 16.1, 15.10.
One-off setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Zed
Every streamer in the library with ranked Zed games, most games first. Each links to their VODs on MID.GG.
Common questions about Zed vs Karthus
What should Zed build against Karthus?
No rune page repeats yet in the 5 high-elo VODs on MID.GG; one game ran the Electrocute rune page, building Voltaic Cyclosword and Edge of Night first.
Which pros and streamers play Zed?
BZ_EUW (241 games), Clid (33) and lol_nemesis (15) have the most Zed VODs on MID.GG, each with their runes, build and full timeline.
Latest Zed vs Karthus games
The most recent games in this matchup, newest first.
- Victory 10/3/9BZ_EUW
Master · Top Patch 16.17 - Victory 3/1/4Cuzz Master · Jungle Patch 16.1
- Victory 12/4/17Oner
Challenger · Jungle Patch 15.10 - Defeat 9/6/5Oner Challenger · Jungle Patch 15.8
- Defeat 4/7/4Pyosik Challenger · Jungle Patch 15.5
