Spear_Shot 
Master 
Clid 
Diamond IV 
Who wins Pantheon vs Karthus?
In the 4 high-elo VODs on MID.GG, Pantheon won 50%.
Pantheon vs Karthus at a glance
VOD library Even Small sample
In 4 high-elo games (latest patch 16.16), Pantheon won 50% against Karthus, so the matchup looks even in our library. The average game ended 11.3/3.8/7.0 for Pantheon. That is a small sample, so treat it as a starting point.
Pro build
The most played Pantheon setup into Karthus takes Conqueror (Precision and Inspiration) and builds Sundered Sky, Black Cleaver and Maw of Malmortius. It shows up in 2 of 4 games with a 50% win rate. The main alternative also takes Conqueror but runs Legend: Alacrity (1 game).
How they built Pantheon into Karthus
Taken from the 4 VODs on this page, patch 16.16, 15.21, 15.12.
Most played setup
Runes
Core items
One-off setup
Runes
Core items
Streamers who play Pantheon
Every streamer in the library with ranked Pantheon games, most games first. Each links to their VODs on MID.GG.
Common questions about Pantheon vs Karthus
What should Pantheon build against Karthus?
The most-played setup is the Conqueror rune page, taken in 2 of the 4 high-elo VODs on MID.GG, with Sundered Sky, Black Cleaver and Maw of Malmortius as its most common core items.
Which pros and streamers play Pantheon?
Spear_Shot (169 games), Clid (25) and Pyosik (14) have the most Pantheon VODs on MID.GG, each with their runes, build and full timeline.
Latest Pantheon vs Karthus games
The most recent games in this matchup, newest first.
- Defeat 9/4/2Spear_Shot
Grandmaster · Jungle Patch 16.16 - Victory 12/2/9Pyosik
Emerald III · Jungle Patch 15.21 - Defeat 14/6/3Sponge
Challenger · Jungle Patch 15.12 - Victory 10/3/14Oner Challenger · Jungle Patch 15.7
